Dysregulation of the B cell compartment leading to chronic GvHD (B10)

• Subject Area: Hematology, Oncology ; Immunology ; Clinical Immunology and Allergology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

In prior work we described elevated circulating IgA+ plasmablasts as early predictors of chronic GvHD. These plasma-blasts home to the gut and produce commensal-binding IgA potentially modulating the microbiota. Aiming to identify biological processes that predict treatment response, we analyze peripheral blood and tissues for dynamic therapy-induced effects on plasma-blasts and B cell trajectories, inflammatory pathways, BCR-repertoire reconstitution, and alterations of T follicular helper cells. The dynamic changes will be correlated with clinical response to standard of care and to CD19 CAR T cell therapy within a clinical trial.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Dr. Fabian Müller, since 1/2026; Professor Dr. Thomas Winkler, until 12/2025; Dr. Julia Winkler, until 12/2025; Professor Dr. Daniel Wolff