Dysregulation of the B-lymphocyte compartment leading to chronic GvHD (B10)

• Subject Area: Hematology, Oncology ; Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

Although experimental data point to a crucial role of B cells and antibody mediated damage in chronic GvHD clinical evidence remains restricted to associations but direct proof is lacking. In this project we characterize clonal B cell subpopulations directly involved in clinical chronic GvHD, identify host specific antibodies and determine their targets. Finally, the effects of different treatment regimens on B cell subpopulations and B cell infiltrations as well as donor-antibody mediated damage of host target tissues will be investigated.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Thomas Winkler; Dr. Julia Winkler; Professor Dr. Daniel Wolff