Die Rolle von Protein-Mineral-Komplexen in der Mineral-Homöostase (C03)

• Subject Area: Biochemistry
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

CKD patients develop extensive and progressive vascular calcification that contributes to the high cardiovascular morbidity and mortality. Calciprotein monomers (CPM) stabilize amorphous calcium-phosphate precursors, which, if they grow and crystallize, start a vicious cycle of cell and matrix calcification and inflammation. This project aims to elucidate the atomic structure of CPM, their stability and biological activity. This may lead to the identification of early-stage, modifiable molecular targets to diagnose and stop CVD and CKD-associated cardiovascular inflammation and calcification, before irreversible vicious cycles have started.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Major Instrumentation: Live Cell Analysis
• Instrumentation Group: 5042 Mikroskope für Hochdurchsatz und Screening
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Professor Dr. Wilhelm Jahnen-Dechent