Project Details
Projekt
Translating high-resolution single cell and spatial omics towards novel therapies for vascular calcification (C05)
Subject Area
Nephrology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
Vascular calcification strongly contributes to cardiovascular risk in CKD. We could define cell types and pathways involved in vascular calcification and generated advanced single cell and spatial atlases of human vascular calcification to define cell types and molecular mechanisms. We now want to translate this knowledge into the development of therapeutic approaches to prevent and/or reduce vascular calcification. Based on our available omics data, we will identify and prioritize drug targets and perform rigorous drug testing. Also, we will elucidate the molecular basis of calcifying uremic arteriolopathy to identify novel diagnostic and therapeutic targets for prevention and reversal of this disease.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Head
Professor Dr. Rafael Kramann
