Project Details
Projekt
Role of the extramedullary hematopoietic system as a driver of CKD-associated CVD (C08)
Subject Area
Nephrology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
CKD represents a pro-inflammatory condition, which drives the development of CKD-associated cardiovascular complications. We identified a reprogramming of the hematopoietic system in the bone marrow of CKD mice and also detected the presence of a hematopoietic system in the kidney, which is altered in response to kidney injury. Therefore, this project aims to unveil important interactions between CKD, CVD and systemic inflammation. We will characterize the contribution of extramedullary hematopoiesis as well as circulating hematopoietic stem and progenitor cells to CVD in CKD and explore the clinical relevance of CKD-associated inflammation in large clinical outcome trials.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Heads
Professor Dr. Danilo Fliser, until 12/2021; Professor Dr. Thimoteus Speer, Ph.D.
