Project Details
Projekt
Role of hematopoietic reprogramming in cardiorenal diseases (C08)
Subject Area
Nephrology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
Inflammation represents a crucial mediator of CKD and CVD alike. Our recent findings underscore the relevance of inflammation in CKD-associated CVD by engaging a specific innate immune pathway, i.e. by NLRP3 inflammasome activation. This project aims to gain novel pathophysiological insights into the effects of CKD and CVD on the hematopoietic compartment and the regulation of hematopoiesis in general. The results obtained should improve the understanding of cardiorenal disease mechanisms and identify novel anti-inflammatory treatment approaches to halt the progression of CKD and the development of its associated cardiovascular complications.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Heads
Professor Dr. Danilo Fliser, until 12/2021; Professor Dr. Thimoteus Speer, Ph.D.
