PDGF ligand-mediated signaling in increased cardiovascular risk in CKD (M01)

• Subject Area: Pathology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

We have previously defined the role of PDGFR in CKD, particularly in mediating fibrosis and angiogenesis. Furthermore, we recently revealed that PDGFR activation is involved in both CKD-associated vascular calcification and cardiomyopathy. Therefore, this project now aims to examine the role of PDGF ligands, particularly the most potent ligand PDGF-B, in uremic cardiomyopathy and vascular calcification in CKD. This could serve as a basis for future translation of PDGF-based therapies to prevent or modulate uremic cardiomyopathy and vascular calcification, ultimately improving cardiovascular outcomes in CKD patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Peter Boor; Professor Dr. Jürgen Floege, until 12/2021