Role of renal sympathetic nerve activation in CKD-associated cardiovascular disease and the development of malignant arrhythmias (M02)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

CKD is associated with atrial pro-arrhythmic remodeling and activation of the sympathetic nervous system, a known trigger for atrial fibrillation. This project aims to deliver deeper insights into the effect of renal sympathetic signaling on the development of malignant arrhythmias in a multifactorial experimental model of cardiovascular comorbidities, as seen in patients with CKD. Furthermore, it will shed light on renal denervation as an interventional tool to prevent cardiac arrhythmia in CVD-associated comorbidities and CKD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Michael Böhm; Dr. Mathias Hohl; Dominik Linz, Ph.D., until 12/2021