Effects of neuromodulation on pro-arrhythmic atrial remodeling and ventricular function in CKD-associated heart failure with preserved ejection fraction (HFpEF) (M02)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

CKD is associated with atrial pro-arrhythmic remodeling and activation of the sympathetic nervous system, a known trigger for atrial fibrillation. We could show that renal denervation inhibits the development of an atrial fibrillation substrate and prevents progression of uremic cardiomyopathy. We now hypothesize that activation of the sympathetic nervous system represents a fundamental pathomechanism contributing to CKD-associated HFpEF. This project will reveal whether renal denervation alone or in combination with SGLT2 inhibition can improve impaired cardiac and renal function in patients suffering from CKD-associated HFpEF.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Michael Böhm; Dr. Mathias Hohl; Dominik Linz, Ph.D., until 12/2021