Calcium and oxidative stress modulation as novel therapy to reduce ferroptosis-induced cardiovascular risk in CKD patients (M04)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

Inflammation is a major factor determining progression of CKD and the development of cardiovascular complications. This project aims to investigate how calcium and ROS signaling drive ferroptosis and contribute to CKD-associated CVD. By uncovering the molecular pathways regulating ferroptosis, ROS and calcium dynamics under uremic conditions, we aim to identify biomarkers, therapeutic targets and strategies to prevent tissue damage and improve outcomes in CKD-associated CVD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Christoph Maack, until 12/2021; Professorin Barbara Anne Niemeyer, Ph.D., since 1/2022; Professorin Leticia Prates Roma, Ph.D.; Professor Dr. Thimoteus Speer, Ph.D., from 1/2022 until 12/2025