Translational approaches targeting myocardial and endothelial dysregulation in CKD (M05)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

Patients with CKD often present with uremic cardiomyopathy and suffer from an increased mortality after myocardial infarction. We found that CKD increases oxidative stress responses in the heart and predisposes the heart to increased cardiac dysfunction post-infarction. This project will now study in more detail the impact of CKD-induced molecular alterations in cardiomyocyte and endothelial function in the context of ischemic, respectively, non-ischemic conditions, and explore novel therapeutic strategies to target dysregulated cellular metabolism in CKD, with a focus on pantothenic acid metabolism.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Nikolaus Albert Helmut Marx; Privatdozentin Dr. Heidi Noels, Ph.D.