Endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models. (B02)

• Subject Area: Biomaterials
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

The aim of this project is biofabrication of perfusable and endothelialized microvascular networks, which will be produced by MEW of sacrificial thermoresponsive polyoxazolines. Particular focus will be placed on adapting the network geometry and the surrounding cell-containing hydrogels to tissue-specific requirements of B and C projects and to the design of appropriate microscopy-compliant bioreactors. Besides, extensive investigations of endothelial function in the fabricated tissue models are planned, including angiogenesis, interactions with circulating cells, barrier function and regulation of physiological processes in the hydrogel-contained cells.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 225: From the fundamentals of biofabrication towards functional tissue models
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professorin Dr. Iwona Cicha, Ph.D.; Professor Dr. Jürgen Groll