Membrane engineering as a tool to control the behavior of mesenchymal stroma cells in biofabrication processes (B05)

• Subject Area: Biomaterials ; Orthopaedics, Traumatology, Reconstructive Surgery
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

This project focuses on the modification of cell surfaces through membrane engineering, integrating new lipid and macromolecular anchor systems as well as bioorthogonally addressable glycostructures into human mesenchymal stromal cells (hMSC) and their interaction partners. The goal is to spatiotemporally control cell proliferation, differentiation, and cell-cell interactions during spheroid formation and biofabrication processes. The project aims to advance the development of highly ordered 3D-printed models, enabling the study of cell-cell interactions, proliferation, and applications in therapeutic research in close collaboration with consortium partners.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 225: From the Fundamentals of Biofabrication towards Functional Tissue Models
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professorin Dr. Regina Ebert; Professor Dr. Lutz Nuhn, Ph.D., since 7/2023; Professor Dr. Jürgen Seibel