Fitness effects of cross-species gene transfer in bacteria (A05)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325931972

The project characterizes the predictability of horizontal gene transfer from specific characteristics of its distribution of fitness effects (DFE). We will measure the DFE for transfer between Bacillus species using random barcoding technology, comparing different growth environments and evolutionary histories of the recipient. We will use the assay to explore mechanisms of transformation and their relative fitness benefits. Together, this project serves to predict speed and temporal order for different functional classes of adaptive transfers.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1310: Predictability in Evolution
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Berenike Maier