Modulation of glioma-neuron networks by immune cells in malignant brain tumors (09)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Molecular and Cellular Neurology and Neuropathology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

The new concept of Brain Border Compartments (BBCs) fundamentally changes the understanding of glioma development and treatment approaches. Particularly the cervical lymph nodes, the dura and the cranial bone marrow interact with the tumor shaping the tumor immune response. Thus, the project aims to unravel how gliomas modify the immunological land-scape of the BBCs to promote immune evasion. Thereby we will concentrate on the immunomodulatory factors EGFL7 and IL4Rα. The final essential step involves the analysis of new glioma treatment regimes by application of immune cell modulators into the BBCs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Mirko H.H. Schmidt; Professorin Dr. Frauke Zipp