Transcriptional regulation and interactomes of viral immune evasion proteins (11)

• Subject Area: Immunology ; Virology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

Cytomegaloviruses are masters in subverting immune response of their respective host, encoding multiple proteins that interfere with cellular ligands needed to activate T or NK cells. In this project, we use advanced mass spectrometry approaches combined with selective in vivo biotinylation of viral immune evasion to define the interactomes of these proteins in the infected cell and identify novel targets for viral immune evasion. We further characterize how cellular transcription factors control the transcription of viral immune evasion proteins to maintain balanced immune responses during viral latency.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Privatdozentin Dr. Ute Distler; Professor Dr. Niels Lemmermann; Professor Dr. Matthias J. Reddehase, until 6/2020