The crosstalk between B cells and myeloid cells during viral and parasitic infection (15)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

B cells mediate humoral immune responses to protect against viral infections. This project aims to investigate how B cells play a role in the CD8+ T cell response against infections. We recently discovered that B cell-deficient mice are unable to mount an efficient CD8+ T cell response after infection with murine cytomegalovirus (MCMV) or Leishmania major. Using the universal LIPSTIC system, this project will investigate how macrophages in the spleen or skin regulate the expansion of Langerin+ cDC1s and how B cells cooperate with CD8+ T cells to regulate an antiviral or Leishmania-specific immune response. We also aim to translate our findings to humans.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin Dr. Esther von Stebut; Professor Dr. Ari Waisman