Mechanisms controlling Th17 and regulatory T cells in the anti-Leishmania response (15)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

Protection against leishmaniasis is promoted via Th1/Tc1 cells, whereas Treg and Th17 cells are responsible for inefficient defence against the parasite. Within this project, we aim to study how cytokines shape the development of pathogenic as well as regulatory T cells and subsequently, to understand how they affect the response in the infected tissue to L. major, focusing particularly on keratinocytes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin Dr. Ruth Esther von Stebut-Borschitz; Professor Dr. Ari Waisman