Reg3-mediated mechanisms in control of UPR and anti-tumor immunity (16)

• Subject Area: Hematology, Oncology ; Gastroenterology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

A proper unfolded protein response (UPR) is essential for tissue homeostasis, regeneration, and carcinogenesis. The lectin regenerating islet-derived protein 3 beta (Reg3β) is well known for its antimicrobial functions and its overexpression induces dysbiosis associated with protection from primary tumor development and metastasis formation in various organs. We identified a novel cell-autonomous function of Reg3 to modulate the UPR in intestinal epithelial cells and aim to unravel Reg3 controlled autocrine and paracrine mechanisms that enable enhanced immune cell function and thus improve therapeutic outcome of advanced tumors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Florian R. Greten; Dr. Nadine Hövelmeyer