Innovative imaging of renal cell carcinoma: Radiogenomics, Radiomics and creation of a new prognostic nomogram
Final Report Abstract
During this Research Fellowship I learned a lot about data science, genomic analysis, radiologic image analysis and machine learning methods. On every day, I found myself surrounded by an interdisciplinary team of scientists, who helped me to create, improve and troubleshoot along the course of my studies. The environment at this institution was always stimulating with regular team meetings and a free exchange of expertise between specialties and departments. Especially the expertise in the field of genomics that I could gather here will help to pursue my goal to establish a tumor sequencing pipeline for genitourinary neoplasms at the University of Munich. At my home institution, I will be involved in the sequencing process of the recently established interdisciplinary Molecular Tumor Board, which uses a targeted sequencing approach. The use of radiomic analysis as an add-on in the field of radiogenomics is promising regarding its use as a biomarker of disease aggressiveness and possible tumor response under systemic therapy. However, any next step first requires the completion of current investigations by our entire team to rule out methodological issues in our radiomic studies.
Publications
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Putative Drivers of Aggressiveness in TCEB1-mutant Renal Cell Carcinoma: An Emerging Entity with Variable Clinical Course. Eur Urol Focus. 2019 Dec 6
DiNatale RG, Gorelick AN, Makarov V, Blum KA, Silagy AW, Freeman B, Chowell D, Marcon J, Mano R, Sanchez A, Attalla K, Weng S, Voss M, Motzer RJ, Russo P, Coleman JA, Reuter VE, Chen YB, Chan TA, Reznik E, Tickoo SK, Hakimi AA
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The Association Between Small Primary Tumor Size and Prognosis in Metastatic Renal Cell Carcinoma: Insights from Two Independent Cohorts of Patients Who Underwent Cytoreductive Nephrectomy. Eur Urol Oncol. 2019. Nov 14
DiNatale RG, Xie WG, Becerra MF, Silagy AW, Attalla K, Mano R, Marcon J, Blum KA, Benfante NE, Voss MH, Motzer RJ, Coleman J, Choueiri TK, Reznik E, Russo P, Heng DYC, Hakimi AA
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The predictive role of preoperative and postoperative neutrophil-lymphocyte ratio in sarcomatoid renal cell carcinoma. Urol Oncol. 2019 Dec;37(12):916-923
Mano R, Flynn J, Blum KA, Silagy AW, DiNatale RG, Marcon J, Wang A, Sanchez A, Coleman JA, Russo P, Ostrovnaya I, Hakimi AA
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The Role of Cytoreductive Nephrectomy for Sarcomatoid Renal Cell Carcinoma: A 29-Year Institutional Experience. Urology. 2020 Feb;136: 169-175
Silagy AW, Mano R, Blum KA, DiNatale RG, Marcon J, Tickoo SK, Reznik E, Coleman JA, Russo P, Hakimi AA
