Project Details
Projekt
Multiscale functional mapping of cell identity decisions in PDAC initiation (P01)
Subject Area
Gastroenterology
Term
from 2018 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492
Pancreatic cancer evolution is characterized by consecutive cellular fate changes through molecular reprogramming. Our understanding of these processes is, however, fragmented. Utilizing unique human cellular model systems and novel screening technologies in mice, this project will chart and functionalize KRAS induced transcriptional, epigenetic and topological changes to create global maps of molecular programs driving early oncogenic cell state transitions. Integrative analyses will focus on the discovery of core transcription factor networks, followed downstream mechanistic studies on critical players, such as Foxp1, a newly identified driver of acinar to ductal metaplasia. The project has potential implications for disease prevention and therapy.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1321:
Modelling and Targeting Pancreatic Cancer
Applicant Institution
Technische Universität München (TUM)
