Functional characterization of the atypical member of the IkappaB inhibitor Bcl-3 in pancreatic ductal adenocarcinoma (P04)

• Subject Area: Gastroenterology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492

The atypical member of the Inhibitor of kappa-B (IkappaB) family of proteins B-cell CLL/lymphoma 3 (Bcl-3) is an established oncogene in hematologic malignancies. Here we demonstrate for the first-time hyperphosphorylation of Bcl-3 in human and murine PDAC. Using various genetic tools we report that hyperphosphorylated Bcl-3 negatively regulates pancreatic carcinogenesis and metastasis. We will elaborate the previously unrecognized role for Bcl-3 and its phosphorylated sites in PDAC and highlight new aspects of Bcl-3 in this disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1321: Modelling and Targeting Pancreatic Cancer
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Dr. Hana Algül