Mechanisms promoting coagulation responses and thrombosis in pancreatic cancer metastasis (P10)

• Subject Area: Gastroenterology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492

The mechanisms triggering intravascular coagulation at sites of pancreatic cancer metastasis and those inducing cancer-associated deep vein thrombosis (DVT) are largely unknown. We will clarify the molecular circuits underlying tumor-triggered microthrombosis and reveal how such thrombi and extracellular vesicles control metastasis using intravital 2-photon fluorescence microscopy. In parallel, procoagulant reactions of immune cells during metastasis will be uncovered. The new molecular targets identified will be examined in models of DVT to enable specific inhibition of cancer-associated thrombosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1321: Modelling and Targeting Pancreatic Cancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Bernd Engelmann; Professor Dr. Steffen Massberg