Role of UNC93B1 in nucleic acid-sensing TLR function - relevance for the pathogenesis of systemic lupus erythematosus (A11)

• Subject Area: Biochemistry ; Immunology ; Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452

This project will elucidate the molecular mechanisms underlying a novel monogenic form of early-onset SLE due to an UNC93B1 gain-of-function. By combining their expertise in pediatric immunology, innate immunity, and systems medicine, the investigators aim at translating basic research findings into novel therapeutic concepts targeting individual innate immune pathways, thus, accelerating precision medicine in autoimmune diseases.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 237: Nucleic Acid Immunity
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Eicke Latz; Professorin Dr. Min Ae Lee-Kirsch, since 1/2023