Characterization of aberrant immune signals driven by inflammatory cell death in cancer (P10)

• Subject Area: Hematology, Oncology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 360372040

In project P10, myeloid leukemias will be used as models of transformed innate cells that retain the capacity to sense inflammation in order to investigate consequences of aberrant inflammatory signal integration and necroptotic cell death on malignant transformation. To drive chronic leukocyte activation and to investigate the roles of distinct TNF receptor and necroptotic pathways on oncogenesis in vivo, as well as the functions of coordinated cytokine signaling within leukemia initiating cells, they will utilize mice expressing an AML-associated mutation in the gene encoding the FLT3 cytokine receptor.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1335: Aberrant Immune Signals in Cancer
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Dr. Philipp Jost