Molecular mechanisms and therapeutic implications of vascular permeability defects in IBD (A06)

• Subject Area: Gastroenterology ; Immunology ; Rheumatology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 375876048

In the previous funding period we found that a breakdown of the intestinal vascular barrier plays a crucial role in the pathogenesis of IBD. Here we will analyze the temporal relation of vessel barrier breakdown and disease development, investigate the molecular mechanisms of inflammation-induced endothelial barrier disruption and determine the angiocrine impact of the inflamed intestinal vasculature on epithelial barrier functions. Finally, we will assess the therapeutic potential of pharmacological blood vessel stabilization in IBD. The ultimate goal of this project is to provide new perspectives for vessel-directed therapy approaches for IBD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 241: Immune-Epithelial Communication in Inflammatory Bowel Diseases
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Privatdozentin Dr. Nathalie Britzen-Laurent; Professor Dr. Michael Stürzl