Transplantat-gerichte immunmodulative Therapie bei Gesichtstransplantation

• Antragsteller: Dr. Martin Kauke
• Fachliche Zuordnung: Zahnheilkunde; Mund-, Kiefer- und Gesichtschirurgie
• Förderung: Förderung von 2018 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 411096918

• Erstellungsjahr: 2021

Zusammenfassung der Projektergebnisse

A large variety of native and allogeneic mucosal lesions can be seen in fVCA patients and their mucous membranes seem to be more frequently affected by pathological processes than previously thought. A close time relation with the development of skin rejection suggest a mechanistic lineage between immunological processes of both tissue types. Mucosal assessment plays an important role in the pleomorphic allograft rejection process evaluation rather than diagnosis and treatment based on skin only pathology. A closer look at the pathophysiology of mucosal rejection seems necessary to better understand the role of the mucosa for monitoring of facial allografts.

Projektbezogene Publikationen (Auswahl)

• 2020. Mucosa and rejection in facial vascularized composite allotransplantation: a systematic review. Transplantation, 104(12), pp.2616-2624
  Kauke, M., Safi, A.F., Zhegibe, A., Haug, V., Kollar, B., Nelms, L., Palmer, W.J., Tchiloemba, B., Lian, C.G., Murphy, G.F. and Pomahac, B.
  (Siehe online unter https://doi.org/10.1097/TP.0000000000003171)
• 2021. Face Transplantation in a Black Patient—Racial Considerations and Early Outcomes. New England Journal of Medicine, 384(11), pp.1075-1076
  Kauke, M., Panayi, A.C., Tchiloemba, B., Diehm, Y.F., Haug, V., Kollar, B., Perry, B., Singhal, D., Sinha, I., Riella, L.V. and Annino, D.J.
  (Siehe online unter https://doi.org/10.1056/nejmc2033961)