Transplant-targeted immunomodulative therapy for face transplantation

• Applicant: Dr. Martin Kauke
• Subject Area: Dentistry, Oral Surgery
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 411096918

• Final Report Year: 2021

Final Report Abstract

A large variety of native and allogeneic mucosal lesions can be seen in fVCA patients and their mucous membranes seem to be more frequently affected by pathological processes than previously thought. A close time relation with the development of skin rejection suggest a mechanistic lineage between immunological processes of both tissue types. Mucosal assessment plays an important role in the pleomorphic allograft rejection process evaluation rather than diagnosis and treatment based on skin only pathology. A closer look at the pathophysiology of mucosal rejection seems necessary to better understand the role of the mucosa for monitoring of facial allografts.

Publications

• 2020. Mucosa and rejection in facial vascularized composite allotransplantation: a systematic review. Transplantation, 104(12), pp.2616-2624
  Kauke, M., Safi, A.F., Zhegibe, A., Haug, V., Kollar, B., Nelms, L., Palmer, W.J., Tchiloemba, B., Lian, C.G., Murphy, G.F. and Pomahac, B.
  (See online at https://doi.org/10.1097/TP.0000000000003171)
• 2021. Face Transplantation in a Black Patient—Racial Considerations and Early Outcomes. New England Journal of Medicine, 384(11), pp.1075-1076
  Kauke, M., Panayi, A.C., Tchiloemba, B., Diehm, Y.F., Haug, V., Kollar, B., Perry, B., Singhal, D., Sinha, I., Riella, L.V. and Annino, D.J.
  (See online at https://doi.org/10.1056/nejmc2033961)