Endocrine communication of renal tubules (C03)

• Subject Area: Anatomy and Physiology ; Nephrology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

The kidneys are important endocrine organs. In addition to specialized endocrine cells, tubular cells also release autacoids and hormones, which act on adjacent cells of the tubules and the interstitium and thus influence kidney function. Our project aims at a better understanding of the regulation of tubular hormones and of their functional importance in the healthy and diseased kidney. Based on preliminary data, we will focus on the local, tubular renin-angiotensin system and tubular natriuretic peptides. Moreover, new tubular hormones, autacoids and metabolites will be identified and their functional significance will be clarified.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Frank Schweda