Structure determination of the closed dimeric conformation of TAp63α and investigation of its CK1 dependent activation

• Applicant: Professor Dr. Volker Dötsch
• Subject Area: Structural Biology ; Biochemistry
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 417339402

• Final Report Year: 2023

No abstract available

Publications

• DNA Damaged Induced Cell Death in Oocytes. Molecules, 25(23), 5714.
  Gebel, Jakob; Tuppi, Marcel; Sänger, Nicole; Schumacher, Björn & Dötsch, Volker
  
• p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Nature Chemical Biology, 16(10), 1078-1086.
  Gebel, Jakob; Tuppi, Marcel; Chaikuad, Apirat; Hötte, Katharina; Schröder, Martin; Schulz, Laura; Löhr, Frank; Gutfreund, Niklas; Finke, Franziska; Henrich, Erik; Mezhyrova, Julija; Lehnert, Ralf; Pampaloni, Francesco; Hummer, Gerhard; Stelzer, Ernst H. K.; Knapp, Stefan & Dötsch, Volker
  
• Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell Death & Differentiation, 29(12), 2445-2458.
  Strubel, Alexander; Münick, Philipp; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas; Gebel, Jakob; Osterburg, Christian; Tuppi, Marcel; Schäfer, Birgit; Knapp, Stefan; Plückthun, Andreas & Dötsch, Volker
  
• Dominant TP63 missense variants lead to constitutive activation and premature ovarian insufficiency. Human Mutation, 43(10), 1443-1453.
  Tucker, Elena J.; Gutfreund, Niklas; Belaud‐Rotureau, Marc‐Antoine; Gilot, David; Brun, Tiffany; Kline, Brianna L.; Bell, Katrina M.; Domin‐Bernhard, Mathilde; Théard, Camille; Touraine, Philippe; Robevska, Gorjana; van den Bergen, Jocelyn; Ayers, Katie L.; Sinclair, Andrew H.; Dötsch, Volker & Jaillard, Sylvie
  
• Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation. Cell Death & Disease, 13(3).
  Fester, Niclas; Zielonka, Elisabeth; Goldmann, Jakob; Frombach, Ann-Sophie; Müller-Kuller, Uta; Gutfreund, Niklas; Riegel, Kristina; Smits, Jos G. A.; Schleiff, Enrico; Rajalingam, Krishnaraj; Zhou, Huiqing; Simm, Stefan & Dötsch, Volker
  
• Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes. Molecular Cell, 82(11), 2006-2020.e8.
  Cullati, Sierra N.; Chaikuad, Apirat; Chen, Jun-Song; Gebel, Jakob; Tesmer, Laura; Zhubi, Rezart; Navarrete-Perea, Jose; Guillen, Rodrigo X.; Gygi, Steven P.; Hummer, Gerhard; Dötsch, Volker; Knapp, Stefan & Gould, Kathleen L.
  
• Structural diversity of p63 and p73 isoforms. Cell Death & Differentiation, 29(5), 921-937.
  Osterburg, Christian & Dötsch, Volker
  
• Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree. Cell Death & Disease, 14(4).
  Osterburg, Christian; Ferniani, Marco; Antonini, Dario; Frombach, Ann-Sophie; D.’Auria, Ludovica; Osterburg, Susanne; Lotz, Rebecca; Löhr, Frank; Kehrloesser, Sebastian; Zhou, Huiqing; Missero, Caterina & Dötsch, Volker