Gut microbiome in renoprotection (A01)

• Subject Area: Gastroenterology ; Biochemistry ; Nephrology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

This project investigates key mechanisms of gut microbiome involvement in hypertensive CKD for identifying new targets in renoprotection. A deeper understanding of microbiota-host interaction in hypertensive CKD is needed, especially with regards to inflammation. Proof-of-concept experiments will be performed in a trans-species approach using microbiome sequencing, metabolomics and immunophenotyping alongside quantification of renal damage, allowing for an integrative network analysis. The effects of commonly used drugs known to interfere with the microbiota as well as the effects of microbiota from CKD patients will be investigated in established rodent models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Sofia Forslund-Startceva; Professor Dr. Dominik N. Müller; Dr. Nicola Wilck