Dilating renal medullary microvessels by the NO-sGC-cGMP pathway for renoprotection (A02)

• Subject Area: Anatomy and Physiology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

We set out to elucidate the protective role of sGC-activation in acute kidney injury and in developing chronic kidney disease by assessing the functional capacity of sGC under hypoxia/re-oxygenation in vitro and after ischemia/re-perfusion ex vivo. Functional investigations on microvessels that supply the area-at-risk for kidney damage performed here are unique. Combining measurements of renal perfusion and autoregulation as well as MR based imaging of renal oxygenation represents a distinctive approach for characterizing substance based, vessel-targeted, renal protection. Inclusion of human medullary microvessels allows translating pharmacological effects into the human setting.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Andreas Patzak, Ph.D.; Professor Dr. Pontus Börje Persson