A renal function of 2,3-bisphosphoglycerate mutase (BPGM) (B01)

• Subject Area: Nephrology ; Anatomy and Physiology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

BPGM generates 2,3-bisphosphoglycerate (2,3-BPG) to reduce oxygen binding to hemoglobin, and improve tissue oxygenation. We show that in the nephron BPGM is constitutively expressed, and up-regulated under conditions such as acute kidney injury, clear cell renal carcinoma, or knock-out of the tumor suppressor von Hippel Lindau protein. Moreover, hypoxia or osmotic stress up-regulate BPGM in kidney cells in vitro. In renal cells BPGM modulates glucose utilization, promotes scavenging of reactive oxygen species, as well as cell survival under stress. We postulate that BPGM is renoprotective.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Michael Fähling; Professor Dr. Christian Rosenberger