Circadian control of microbial function in chronic intestinal inflammation (P03#)

• Subject Area: Anatomy and Physiology ; Gastroenterology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 395357507

Disruption of intrinsic clocks, e.g. by mismatch of the external and internal daytime in shift workers, as well as microbiota dysbiosis promote the development of inflammatory bowel diseases (IBD). This project examines which clock controls daytime-dependent fluctuations in microbiota composition and function. Microbiota transfer from clock-deficient mice in IBD-relevant mouse models will test the hypothesis whether the loss of microbiota fluctuations plays a key role in the development of IBD. Restoring the colon clock in an IBD-relevant mouse model by time-restricted feeding will determine whether the intestinal clock can be a target for future treatment strategies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1371: Microbiome Signatures -- Functional Relevance in the Digestive Tract
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Dr. Silke Kiessling