The role of primary metabolites in the intestinal ecosystem under normal and inflamed conditions (P08)

• Subject Area: Biochemistry ; Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 395357507

Inflammatory processes create metabolic and trophic niches in the gut which, in turn, affect the composition and function of the microbial ecosystem. Project P08 will investigate the role of primary luminal metabolites, specifically organic acids and polyamines and characterize the impact of sensing, uptake and metabolic interactions on the fitness and growth of disease-relevant Salmonella, Desulfovibrio, Enterococcus and the individual species of the microbiota. Analyses will be done in vitro and in gnotobiotic mice colonized with the minimal bacterial consortium Oligo-MM and other mouse models of gut inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1371: Microbiome Signatures -- Functional Relevance in the Digestive Tract
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professorin Dr. Kirsten Jung; Professorin Dr. Barbara Stecher