Project Details
Projekt
Physiological impact of ClpP modulators on bacteria and mitochondria (A01)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
from 2019 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 398967434
The caseinolytic protease Clp plays a central role in protein homeostasis and regulatory proteolysis in bacteria and mitochondria and is a target for antibacterial, anti-virulence, and antitumor therapy. We investigate two classes of modulators of the proteolytic core ClpP of the complex protease. ADEP antibiotics activate ClpP and lead to uncontrolled protein digestion. Here, we explore the altered substrate spectrum. For a new natural product class inhibiting ClpP, we investigate the mechanism of producer self-protection.
DFG Programme
CRC/Transregios
Applicant Institution
Eberhard Karls Universität Tübingen
Project Head
Professorin Dr. Heike Brötz-Oesterhelt
