Project Details
Projekt
Impact of carba-glucosamine on bacterial cell metabolism (A03)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
from 2019 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 398967434
The treatment of Bacillus subtilis and Staphylococcus aureus with carba-alpha-D-glucosamine (CGlcN) induces bacterial growth inhibition. This inhibition has been found to depend on the presence of a specific phosphoenolypyruvate-phosphosugar transferase system. This suggests that upon bacterial uptake, CGlcN is transformed into carba-alpha-D-glucosamine-6-phosphate (CGlcN6P), which has been shown to activate the glmS riboswitch. This activation leads to a reduced expression of the GlmS protein, a key enzyme for the synthesis of cell wall precursors, and consequently to bacterial growth inhibition. Our goal is to analyze the detailed molecular impact of CGlcN on cellular metabolism and growth.
DFG Programme
CRC/Transregios
Applicant Institution
Eberhard Karls Universität Tübingen
Project Head
Professor Dr. Günter Mayer
