LncRNA control of cardiac inflammation (B03)

• Subject Area: Cell Biology ; Cardiology, Angiology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

In the previous funding period, we showed that inhibition of the lncRNA Ntras in mice induces cardiac inflammation. Overshooting inflammation is an important contributor to heart failure. Therefore, we will characterize the mechanisms how Ntras deficiency induces this phenotype. Ntras is enriched in cardiac endothelial cells but is also expressed in leukocytes, which work synergistically for mounting inflammatory responses. We will determine whether and how Ntras expression in endothelial cells, leukocytes, or both, restricts cardiac inflammation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Privatdozent Dr. Sebastian Cremer, since 7/2023; Professorin Dr. Stefanie Dimmeler; Dr. Nicolas Jaé, until 6/2023