Project Details
Projekt
Non-coding RNA control of cardiac repolarisation (B09)
Subject Area
Pharmacology
Term
from 2019 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255
The role for ncRNAs in myocyte electrophysiology is still largely unclear. Our preliminary data indicate that miR-365 regulates multiple repolarising ion channels at the posttranscriptional level. This project aims to resolve its mechanism of action, its targets and the effects of its manipulation. Moreover, we want to determine whether miR-365 exerts a role in electrical remodelling, e.g. in cardiac hypertrophy. Our models are hiPS cells from healthy donors or patients with QT syndromes, which we differentiate to cardiac myocytes. In this background, we will manipulate miR-365 and determine its effects on action potential characteristics next to other relevant parameters. Finally, we will also characterise other cardiac myocyte ncRNAs that we have identified, to provide the first comprehensive insight into the role of ncRNAs in cardiac rhythm control.
DFG Programme
CRC/Transregios
Subproject of
TRR 267:
Non-coding RNA in the cardiovascular system
Applicant Institution
Technische Universität München (TUM)
