Prefrontal control of emotion regulation and alternative reward in tobacco use disorder (B05)

• Subject Area: Biological Psychology and Cognitive Neuroscience ; Biological Psychiatry ; Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry ; Human Cognitive and Systems Neuroscience ; Cognitive, Systems and Behavioural Neurobiology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 402170461

To acquire long term data regarding severity of tobacco use disorder (TUD) and the use of alternative rewards, we will perform a 10 year follow-up study of the well characterized (e.g. EEG, genetics, clinical phenotyping, neuropsychology) National Nicotine Cohort study comprising nearly 2400 subjects. We will contact all of them, acquire new data (in particular smoking status, emotion regulation, use of alternative reward) and we will investigate the prediction of outcome using machine learning approaches. We will recall a subset of theparticipants (N=120), investigate them experimentally with EEG, simultaneous EEG/fMRI (resting state), and fMRI (emotion regulation paradigms regarding negative affect and craving) in order to elucidate mechanisms of prefrontal control regarding reward preference in TUD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 265: Losing and Regaining Control over Drug Intake: From Trajectories to Mechanisms to Interventions
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Henrik Walter; Professor Dr. Georg Winterer