Proteolytically resistant gluten peptides (PRGPs) and their nanostructures in health and disease

• Applicant: Dr. Veronica Isabel Dodero Bendana
• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 430578458

Gluten-related disorders (GRDs), affecting approximately 5% of the global population, arise from the incomplete digestion of wheat gluten proteins, leading to the formation of proteolytically resistant gluten peptides (PRGPs). These PRGPs, rich in proline and glutamine, are pivotal in the pathomechanism of GRDs, including celiac disease (CeD), gluten ataxia, and non-celiac gluten or wheat sensitivity (NCWS). Despite significant advancements, the early molecular events triggering these disorders remain unclear. PRGPs can self-assemble into oligomers and fibrils, which may precede inflammation and play a role in disease onset. This project aims to elucidate the mechanisms of PRGP oligomerization and their interactions with key cellular proteins such as actin, actin-binding proteins, tight junctions, and toll-like receptors (TLRs). By understanding these processes, we aim to identify novel therapeutic targets and dietary interventions, ultimately improving health outcomes for individuals with GRDs.

• DFG Programme: Research Grants