The role of LARP7 in RNA modification and its implication for spermatogenesis

• Applicants: Professor Dr. Utz Fischer; Professor Dr. Gunter Meister
• Subject Area: Cell Biology ; Biochemistry
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431572152

• Final Report Year: 2025

No abstract available

Publications

• LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Molecular Cell, 77(5), 999-1013.e6.
  Wang, Xin; Li, Zhi-Tong; Yan, Yue; Lin, Penghui; Tang, Wei; Hasler, Daniele; Meduri, Rajyalakshmi; Li, Ye; Hua, Min-Min; Qi, Hui-Tao; Lin, Di-Hang; Shi, Hui-Juan; Hui, Jingyi; Li, Jinsong; Li, Dangsheng; Yang, Jian-Hua; Lin, Jinzhong; Meister, Gunter; Fischer, Utz & Liu, Mo-Fang
  
• Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism. RNA Biology, 18(2), 290-303.
  Hasler, Daniele; Meister, Gunter & Fischer, Utz
  
• The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. Molecular Cell, 77(5), 1014-1031.e13.
  Hasler, Daniele; Meduri, Rajyalakshmi; Bąk, Maciej; Lehmann, Gerhard; Heizinger, Leonhard; Wang, Xin; Li, Zhi-Tong; Sement, François M.; Bruckmann, Astrid; Dock-Bregeon, Anne-Catherine; Merkl, Rainer; Kalb, Reinhard; Grauer, Eva; Kunstmann, Erdmute; Zavolan, Mihaela; Liu, Mo-Fang; Fischer, Utz & Meister, Gunter
  
• Interaction of 7SK with the Smn complex modulates snRNP production. Nature Communications, 12(1).
  Ji, Changhe; Bader, Jakob; Ramanathan, Pradhipa; Hennlein, Luisa; Meissner, Felix; Jablonka, Sibylle; Mann, Matthias; Fischer, Utz; Sendtner, Michael & Briese, Michael
  
• hnRNP R negatively regulates transcription by modulating the association of P‐TEFb with 7SK and BRD4. EMBO reports, 23(9).
  Ji, Changhe; Deng, Chunchu; Antor, Katharina; Bischler, Thorsten; Schneider, Cornelius; Fischer, Utz; Sendtner, Michael & Briese, Michael
  
• The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription. PLOS Pathogens, 18(2), e1010266.
  Cordsmeier, Arne; Rinkel, Sven; Jeninga, Myriam; Schulze-Luehrmann, Jan; Ölke, Martha; Schmid, Benedikt; Hasler, Daniele; Meister, Gunter; Häcker, Georg; Petter, Michaela; Beare, Paul A. & Lührmann, Anja