Computational Optimization of Piezoelectric Scaffolds for Bone Regeneration (COPs)

• Applicants: Professorin Dr. Sara Checa Esteban, Ph.D.; Professor Dr.-Ing. Manfred W. Zehn
• Subject Area: Biomaterials ; Orthopaedics, Traumatology, Reconstructive Surgery
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 435260927

The aim of this study is to investigate the role of piezoelectricity on scaffold supported bone regeneration. Our long-term goal is to use this understanding for the design optimization of piezoelectric scaffolds to treat large bone defects. We aim to employ mathematical and computational techniques to determine locally the mechanical and electrical signals generated due to the physiological stimulation of a piezoelectric scaffold and to investigate how these signals influence the bone regeneration process. We will investigate how different parameters such as applied deformation, electric field (voltage), frequency, duration of stimulation etc. will influence the bone healing process.

• DFG Programme: Research Grants
• Co-Investigators: Dr.-Ing. Dragan Marinkovic; Dr.-Ing. Melika Mohammadkhah, Ph.D.