Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach (A02)

• Subject Area: Biochemistry ; Biophysics ; Cell Biology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

Classical genetic and chemical tools do not allow studying the cross-talk between dying and bystander cells in a spatially and temporally resolved manner. The project develops optogenetically regulated systems allowing the precisely controlled induction of different forms of cell death at a single cell level, and uses them to study the cross-talk between dying and bystander cells in vitro and in vivo. By employing selective light-controlled activation of different death effectors, this project will study how the different types of cell death shape tissue responses and the underlying mechanisms.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Heads: Professorin Dr. Ana Jesús Garcia Sáez; Professor Dr. Manolis Pasparakis