Cardiomyocyte-Specific MOF Depletion: Heterocellular Effects Driving Cardiac Fibrosis (A04+ (P04))

• Subject Area: Cell Biology ; Developmental Biology
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 422681845

This project explores cell type-specific subcellular functions of the histone acetyltransferase MOF in vivo. Muscle-specific ablation of MOF leads to cardiac failure, remodelling and fibrosis. P04 will use single cell RNA-seq to reveal the dynamics of cardiac remodelling, and to identify primary and secondary functions of MOF in the heterocellular heart. In vitro studies will identify the roles of MOF in cell differentiation and tissue fibrosis, and establish the chromatin binding landscape of MOF in normal and remodelled human myocardium.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1425: Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Asifa Akhtar, Ph.D.