Mineralocorticoid Receptors as Key Regulators of Cardiac Lesions (A05 (P05))

• Subject Area: Cardiology, Angiology ; Pharmacology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 422681845

This project analyses mechanisms of transcriptional control in right ventricular (RV) and atrial remodelling, focusing on the mineralocorticoid receptor (MR). MR, a nuclear transcription factor, is a key player in left ventricular (LV) remodelling. Despite a common final pathway, leading to fibrosis and dysfunction, the molecular basis of RV and atrial remodelling is less well understood than that in LV, and it has not been addressed therapeutically. P05 will (i) identify the cell types in which MR contributes to RV and atrial remodelling (using cell type-specific MR deletion mouse models) and (ii) investigate epigenetic mechanisms that determine cell type-specific transcriptional regulation by MR, with the aim of identifying potential targets for pharmacological modulation of RV and atrial remodelling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1425: Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Privatdozent Dr. Achim Lother