The Impact of Heterogeneous Macrophage Origins on Ischaemic and Non-Ischaemic Cardiac Lesions (B08 (P08))

• Subject Area: Cell Biology ; Cardiology, Angiology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 422681845

This project investigates functional macrophage diversity in the heart, focusing on cell ontogeny. Taking advan¬tage of cell-specific and inducible Cre-Lox mice, P08 will decipher the relative contri¬bution of recruited vs resident cardiac M to healing of and electrical conduction in focal and global lesions after MI and TAC, respectively. Based on novel pathomechanistic insight, it will distinguish beneficial from harmful effects that one or the other M population may exert directly or indirectly via influencing neighbouring cardiomyocytes, or other non-myocytes, and compare murine data to porcine and human tissue. As a result, the project aims to identify potential therapeutic targets for immune-modulation of lesion development.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1425: Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Ingo Hilgendorf