Project Details
Projekt
Local TH transport and action in ischaemic brain injury (P08)
Subject Area
Clinical Neurology; Neurosurgery and Neuroradiology
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847
Aim of this project is to clarify the time- and cell-specific requirements of TH transport and action for improved outcome in ischaemic brain injury. Cell-specific TH transporter KO mice will be analysed in the experimental stroke model of transient middle cerebral artery occlusion (MCAO) to elucidate the role of TH transport in different cell-types of the blood brain barrier. Treatment with T3 at different dosages and time points will be used to identify the optimal conditions for intervention. The impact of TH on stroke outcome will be analysed by functional, morphological and imaging techniques, e.g. light sheet microscopy and spatial proteomics.
DFG Programme
CRC/Transregios
Subproject of
TRR 296:
Local control of TH action (LocoTact)
Applicant Institution
Universität Duisburg-Essen
