TH receptor α1 at the crossroad of autonomic and cardiac functions in mice (P12)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

TH is of great importance for cardiac rhythmicity, as tachycardia is often observed in hyperthyroidism, while bradycardia is a leading symptom in hypothyroid patients. It is commonly assumed that the regulation of heart rate by TH is predominantly an effect of TH within the heart; however, recent studies showed that also central TH actions contribute to this phenotype. In the proposed project we now aim to dissect the local from the central actions of TH in the control of heart rate with a focus on the predominant receptor in heart and brain, TRα1.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Jens Mittag