Control of cellular TH metabolism in human and mouse NASH (P14)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

Hepatic TRβ signalling is impaired in human and murine NASH, and vice versa, elevating hepatic TH action improves non-alcoholic hepatosteatosis (NASH). Using human liver biopsies, NASH mouse models and iPSC-derived hepatocytes, we aim to identify the mechanisms that cause reduced TRβ expression in NASH, testing the hypothesis that this is mediated by epigenetic mechanisms involving miRNA and DNA methylation. Finally, we hypothesise that improving hepatic TRβ signalling in NASH will improve current treatment strategies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professorin Dr. Henriette Kirchner; Professor Dr. Jens Mittag